Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR.
Jake R Thomas,
Anna Appios,
Emily F Calderbank,
Nagisa Yoshida,
Xiaohui Zhao,
Russell S Hamilton,
Ashley Moffett,
Andrew Sharkey,
Elisa Laurenti,
Courtney W Hanna,
Naomi McGovern
Apr 17, 2023
The earliest macrophages are generated during embryonic development from erythro-myeloid progenitors (EMPs) via primitive haematopoiesis. Although this process is thought to be spatially restricted to the yolk sac in the mouse...